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OBJECTIVE - We examined the cross-sectional association between objectively measured free-living physical activity energy expenditure (PAEE) and glucose tolerance in adult Cameroonians without known diabetes.
RESEARCH DESIGN AND METHODS - PAEE was measured in 34 volunteers using the doubly labeled water method and indirect calorimetry (resting). Fasting blood glucose and 2-h postload blood glucose were measured during a standard 75-g oral glucose tolerance test.
RESULTS - There was a significant negative correlation between PAEE and 2-h glucose (r = -0.43; P = 0.01) but not fasting glucose (r = 0.1; P = 0.57). The inverse association between PAEE and 2-h glucose remained after adjustment for age, sex, smoking, alcohol consumption, and BMl (ß = -0.017 [95% CI -0.033 to -0.002]) and was unchanged after further adjustment for waist circumference, body fat percentage, or aerobic fitness.
CONCLUSIONS - PAEE is inversely associated with 2-h glucose independently of adiposity or fitness. Interventions aimed at increasing PAEE could play an important role in diabetes prevention in developing countries.
Diabetes Care 32:367-369, 2009
Developing countries are undergoing a rapid epidemiologic transition characterized by rising prevalence of obesity, diabetes, and cardiovascular diseases (CVDs). Recent changes in diet and physical activity patterns have been suggested as possible risk factors (1). It is important to understand the association between modifiable exposure variables and risk factors for chronic diseases in order to design appropriate intervention strategies. We examined the crosssectional association between physical activity energy expenditure (PAEE) and glucose tolerance in nondiabetic adult Cameroonians.
RESEARCH DESIGN AND METHODS - A cross-sectional study of 17 men and 17 women recruited from an urban and a rural residential area of Cameroon was conducted. Ethical approval for the study was obtained from the Cameroon National Ethics Committee, and all participants provided signed informed consent.
Height and waist circumference were measured using standard clinical procedures. Body weight was measured using an electronic scale (Tanita TBF-531; Tanita U.K., Middlesex, U.K.). Total body water (TBW) was measured by deuterium dilution. Fat-free mass was calculated from TBW, assuming a hydration factor of 73%, and fat mass derived as the difference between body weight and fat-free mass.
Resting energy expenditure (REE) was measured using the MedGem handheld indirect calorimeter (HealtheTech Inc., Golden, CO). Total energy expenditure (TEE) was measured by...